Methylenetetrahydrofolate dehydrogenase – role in cell growth and expression in stem cells

Results 115 of 15 citing Mejia: NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells.

Substrate flux through methylenetetrahydrofolate dehydrogenase: predicted effects of the …Find It @ MUgroup of 3 »
JM Green, RE MacKenzie, RG Matthews – Biochemistry, 1988 –
Page 1. 8014 Biochemistry 1988, 27, 8014-8022 Kuo, DJ, & Rose, I. A. (1987)
Biochemistry 26, 7589-7596. Metzler, DE (1957) J. Am. Chem. SOC. 79, 485.
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“…predicted effects of the concentration of methylenetrtrahydroflate on its partitioning into pathways leading to nucleotide biosynthesis or methionine regeneration”

Mammalian Fibroblasts Lacking Mitochondrial NAD+-dependent Methylenetetrahydrofolate Dehydrogenase- …Find It @ MUgroup of 4 »
H Patel, ED Pietro, RE MacKenzie – Journal of Biological Chemistry, 2003 –
Originally published In Press as doi:10.1074/jbc.M301718200 on March 19, 2003
J. Biol. Chem., Vol. 278, Issue 21, 19436-19441, May 23, 2003
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“…are glycine auxotrophs” 

Auxotrophy is the inability of an organism to synthesize a particular organic compound required for its growth (as defined by IUPAC). An auxotroph is an organism that displays this characteristic;

Methylenetetrahydrofolate reductase (MTHFR) is an enzyme (EC that exists in the cytoplasm of cells. MTHFR contains a bound flavin cofactor and uses NAD(P)H as the reducing agent.

MTHFR irreversibly reduces 5,10-methylenetetrahydrofolate (substrate) to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate is used to convert homocysteine (a potentially toxic amino acid) to methionine by the enzyme Methionine synthase.


The expression of mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase supports a role in rapid cell growth

The expression of mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase supports a …group of 2 »
E Di Pietro, XL Wang, RE MacKenzie – Biochim Biophys Acta, 2004 –
Biochim Biophys Acta. 2004 Sep 6;1674(1):78-84.
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Mitochondrial NAD-Dependent Methylenetetrahydrofolate Dehydrogenase-Methenyltetrahydrofolate Cyclohydrolase Is Essential for Embryonic Development

Mitochondrial NAD-Dependent Methylenetetrahydrofolate Dehydrogenase-Methenyltetrahydrofolate …Find It @ MUgroup of 5 »
E Di Pietro, J Sirois, ML Tremblay, RE MacKenzie – Molecular and Cellular Biology, 2002 –
MCB EC Online 2003 Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Abstract of this Article ( ). PDF Version of this Article.
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