NRF2 Papers: regulation, aging, micorarray and KO studies

Redox Regulation:

H. Liu, R. Colavitti, I. I. Rovira, and T. Finkel
Redox-Dependent Transcriptional Regulation
Circ. Res., November 11, 2005; 97(10): 967 – 974.
[Abstract] [Full Text] [PDF]

 NRF2 regulation:

 S. Dhakshinamoorthy, A. K. Jain, D. A. Bloom, and A. K. Jaiswal
Bach1 Competes with Nrf2 Leading to Negative Regulation of the Antioxidant Response Element (ARE)-mediated NAD(P)H:Quinone Oxidoreductase 1 Gene Expression and Induction in Response to Antioxidants
J. Biol. Chem., April 29, 2005; 280(17): 16891 – 16900.
[Abstract] [Full Text] [PDF]

 K. Sankaranarayanan and A. K. Jaiswal
Nrf3 Negatively Regulates Antioxidant-response Element-mediated Expression and Antioxidant Induction of NAD(P)H:Quinone Oxidoreductase1 Gene
J. Biol. Chem., December 3, 2004; 279(49): 50810 – 50817.
[Abstract] [Full Text] [PDF]

 M. McMahon, N. Thomas, K. Itoh, M. Yamamoto, and J. D. Hayes
Redox-regulated Turnover of Nrf2 Is Determined by at Least Two Separate Protein Domains, the Redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron
J. Biol. Chem., July 23, 2004; 279(30): 31556 – 31567.
[Abstract] [Full Text] [PDF]

 S. Numazawa, M. Ishikawa, A. Yoshida, S. Tanaka, and T. Yoshida
Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress
Am J Physiol Cell Physiol, August 1, 2003; 285(2): C334 – 342.
[Abstract] [Full Text] [PDF]

 R. Yu, C. Chen, Y.-Y. Mo, V. Hebbar, E. D. Owuor, T.-H. Tan, and A.-N. T. Kong
Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism
J. Biol. Chem., December 15, 2000; 275(51): 39907 – 39913.
[Abstract] [Full Text] [PDF]

 S. Dhakshinamoorthy and A. K. Jaiswal
Small Maf (MafG and MafK) Proteins Negatively Regulate Antioxidant Response Element-mediated Expression and Antioxidant Induction of the NAD(P)H:Quinone Oxidoreductase1 Gene
J. Biol. Chem., December 15, 2000; 275(51): 40134 – 40141.
[Abstract] [Full Text] [PDF]

 T. Nguyen, H. C. Huang, and C. B. Pickett
Transcriptional Regulation of the Antioxidant Response Element. ACTIVATION BY Nrf2 AND REPRESSION BY MafK
J. Biol. Chem., May 12, 2000; 275(20): 15466 – 15473.
[Abstract] [Full Text] [PDF]

 R. Yu, S. Mandlekar, W. Lei, W. E. Fahl, T.-H. Tan, and A.-N. T. Kong
p38 Mitogen-activated Protein Kinase Negatively Regulates the Induction of Phase II Drug-metabolizing Enzymes That Detoxify Carcinogens
J. Biol. Chem., January 28, 2000; 275(4): 2322 – 2327.
[Abstract] [Full Text] [PDF]

 R. Yu, W. Lei, S. Mandlekar, M. J. Weber, C. J. Der, J. Wu, and A.-N. T. Kong
Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals
J. Biol. Chem., September 24, 1999; 274(39): 27545 – 27552.
[Abstract] [Full Text] [PDF]

NRF2 decline in aging:

 J. H. Suh, S. V. Shenvi, B. M. Dixon, H. Liu, A. K. Jaiswal, R.-M. Liu, and T. M. Hagen
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
PNAS, March 9, 2004; 101(10): 3381 – 3386.
[Abstract] [Full Text] [PDF]

NRF2 NO phenotypes: 

L. Leung, M. Kwong, S. Hou, C. Lee, and J. Y. Chan
Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress
J. Biol. Chem., November 28, 2003; 278(48): 48021 – 48029.
[Abstract] [Full Text] [PDF]

NRF2 microarray studies:

 J.-M. Lee, M. J. Calkins, K. Chan, Y. W. Kan, and J. A. Johnson
Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis
J. Biol. Chem., April 4, 2003; 278(14): 12029 – 12038.
[Abstract] [Full Text] [PDF]


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