caloric restriction ribosylation

Sir2 links chromatin silencing, metabolism, and agingFind It @ MUgroup of 8 »
L Guarente – 2000 – genesdev.org
DNA repair-associated ADP-ribosylation in vivo: Modification of histone H1 differs
from that of The genetics of caloric restriction in Caenorhabditis elegans.
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Sir 2: An NAD-dependent Histone Deacetylase That Connects Chromatin Silencing, Metabolism, and AgingFind It @ MUgroup of 4 »
S IMAI, FB JOHNSON, RA MARCINIAK, M MCVEY, PU PARK … – Cold Spring Harbor Symposia on Quantitative Biology, 2000 – Cold Spring Harbor
DNA repair-associated ADP-ribosylation in vivo: Modifica- tion of histone H1 Gene
expression profile of aging and its retardation by caloric restriction.
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Sound silencing: the Sir 2 protein and cellular senescenceFind It @ MUgroup of 3 »
PA Defossez, SJ Lin, DS McNabb – BioEssays, 2001 – doi.wiley.com
While these data do not completely rule out ADP- ribosylation as being An intervention
resembling caloric restriction prolongs life span and retards aging in
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THE SIR 2 FAMILY OF PROTEIN DEACETYLASESFind It @ MUgroup of 5 »
G Blander, L Guarente – Annual Review of Biochemistry, 2004 – upo.es
430 CALORIC RESTRICTION . that of the substrate by 42 Da, indicating that the major
modification catalyzed by Sir2 was deacetylation and not ADP-ribosylation.
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Diversity in the Sir2 family of protein deacetylasesgroup of 8 »
SW Buck, CM Gallo, JS Smith – Journal of Leukocyte Biology, 424 – jleukbio.org
of the NAD + salvage pathway are required for caloric restriction-induced longevity
exerting its effects on silencing through the ADP ribosylation of histones
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SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in …Find It @ MUgroup of 4 »
T Shi, F Wang, E Stieren, Q Tong – Journal of Biological Chemistry, 2005 – jbc.org
ribosylation (13) and protein deacetylase activities (14–16). Blocking NAD synthesis
in yeast abolishes the life span extension of caloric restriction (17).
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Small molecule regulation of Sir2 protein deacetylasesFind It @ MUgroup of 5 »
O Grubisha, BC Smith, JM Denu – 2005 – Blackwell Synergy
the ADP-ribose moiety of NAD + and undergo mono-ADP-ribosylation [18]. Originally,
caloric restriction (CR) in yeast was thought to increase the NAD + levels
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The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylasesgroup of 6 »
J Landry, A Sutton, ST Tafrov, RC Heller, J … – 2000 – pnas.org
Finally, the H4 peptide shows no evidence for ADP-ribosylation in the HPLC Lin, E.
Ford, M. Haigis, G. Liszt, and L. Guarente Calorie restriction extends yeast
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