Mitochondria Biogenesis, NRF2, and transcriptional memory related papers

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through …group of 4 »
K Itoh, T Chiba, S Takahashi, T Ishii, K Igarashi, … –
Click here to read An Nrf2/small Maf heterodimer mediates the induction of phase
II detoxifying enzyme genes through antioxidant response elements.
Cited by 346Related ArticlesCachedWeb SearchImport into EndNoteFind It @ MUBL Direct

what is MAF?


Articles that cited:
NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators
CA Virbasius, JV Virbasius and RC Scarpulla
Department of Cell, Molecular, and Structural Biology, Northwestern University Medical School, Chicago, Illinois 60611.

Nuclear respiratory factor 1 (NRF-1) was first discovered as an activator of the cytochrome c gene and was subsequently found to play a broader role in nuclear-mitochondrial interactions. We have now cloned a HeLa cDNA encoding NRF-1 using degenerate oligomers derived from tryptic peptide sequences for PCR amplification. The cDNA-encoded protein was indistinguishable from the authentic HeLa cell factor on denaturing gels, displayed the expected NRF-1 DNA-binding specificity, and made the same guanine nucleotide contacts as HeLa NRF-1 on binding known NRF-1 recognition sites. Antiserum raised against the highly purified recombinant protein recognized the identical DNA-protein complex formed using either a crude nuclear fraction or nearly homogeneous HeLa NRF-1. Recombinant NRF-1 also activated transcription through specific sites from several NRF-1-responsive promoters, confirming both the transcriptional activity and specificity of the cDNA product. Portions of NRF-1 are closely related to sea urchin P3A2 and the erect wing (EWG) protein of Drosophila. Both are recently identified developmental regulatory factors. The region of highest sequence identity with P3A2 and EWG was in the amino-terminal half of the molecule, which was found by deletion mapping to contain the DNA- binding domain, whereas the carboxy-terminal half of NRF-1 was highly divergent from both proteins. The DNA-binding domain in these molecules is unrelated to motifs found commonly in DNA-binding proteins; thus, NRF-1, P3A2, and EWG represent the founding members of a new class of highly conserved sequence-specific regulatory factors.

NRF1- also acronym for Nuclear respiratory factor!!!

B. N. Finck and D. P. Kelly
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
J. Clin. Invest., March 1, 2006; 116(3): 615 – 622.
[Abstract] [Full Text] [PDF]

L. Mercy, A. d. Pauw, L. Payen, S. Tejerina, A. Houbion, C. Demazy, M. Raes, P. Renard, and T. Arnould
Mitochondrial biogenesis in mtDNA-depleted cells involves a Ca2+-dependent pathway and a reduced mitochondrial protein import
FEBS J., October 1, 2005; 272(19): 5031 – 5055.
[Abstract] [Full Text] [PDF]

N. Gleyzer, K. Vercauteren, and R. C. Scarpulla
Control of Mitochondrial Transcription Specificity Factors (TFB1M and TFB2M) by Nuclear Respiratory Factors (NRF-1 and NRF-2) and PGC-1 Family Coactivators
Mol. Cell. Biol., February 15, 2005; 25(4): 1354 – 1366.
[Abstract] [Full Text] [PDF]

D. P. Kelly and R. C. Scarpulla
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Genes & Dev., February 15, 2004; 18(4): 357 – 368.
[Full Text] [PDF]


“NRF1 KEAP1” Scholar search

KEAP1 mutant may not exhibit any phenotype since NRF1 and/or other transcription factors may also activate ARE genes. Is there a NRF1 substrate adaptor protein?

Way to pull out ARE transcription factors

take ARE sequence–>use chip or some other method to pull out proteins interacting –> identification by Mass Spec

use siRNA to knock out BTB-Kelch proteins : look at mRNA sequence corresponding to the domains and create siRNA targeting vector that can KO activity.

Nrf 1 is targeted to the ER membrane by a N-terminal transmembrane domain: inhibition of nuclear …Find It @ MUgroup of 3 »
W Wang, JY Chan – Journal of Biological Chemistry, 2006 –
Although coimmunoprecipitation studies showed that Nrf1 and Keap1 interact directly
with each other through the Neh2-like domain of Nrf1, the Neh2-like domain
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NRF1 localized to ER NRF2 localized to Nucleus?

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response …group of 5 »
R Venugopal, AK Jaiswal – 1996 –
by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified
by M. Kwong, S. Hou, C. Lee, and JY Chan Deficiency of the Nrf1 and Nrf2
Cited by 195Related ArticlesWeb SearchImport into EndNoteBL Direct

Mechanisms of transcriptional Memory
How can the same gene remember that it is ‘off’ in one cell lineage and ‘on’ in another? Studies of how homeotic genes are regulated in Drosophila melanogaster have uncovered a transcriptional maintenance system, encoded by the Polycomb and trithorax group genes, that preserves expression patterns across development. Here we try to formulate a broad framework for the types of molecular mechanism used by the Polycomb and trithorax proteins.
G. M. Martin
Epigenetic drift in aging identical twins
PNAS, July 26, 2005; 102(30): 10413 – 10414.
[Full Text] [PDF]

V. R. Russanova, T. H. Hirai, A. V. Tchernov, and B. H. Howard
Mapping Development-Related and Age-Related Chromatin Remodeling by a High Throughput ChIP-HPLC Approach
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2004; 59(12): 1234 – 1243.
[Abstract] [Full Text] [PDF]

V. R. Russanova, T. H. Hirai, and B. H. Howard
Semirandom Sampling to Detect Differentiation-Related and Age-Related Epigenome Remodeling
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2004; 59(12): 1221 – 1233.
[Abstract] [Full Text] [PDF]

From The Cover: Epigenetic differences arise during the lifetime of monozygotic twins
PNAS, July 26, 2005; 102(30): 10604 – 10609.
[Abstract] [Full Text] [PDF]

How lifetimes shape epigenotype within and across generations
Hum. Mol. Genet., October 15, 2006; 15(suppl_2): R131 – R137.
[Abstract] [Full Text] [PDF]

Y.-S. Keum, S. Yu, P. P.-J. Chang, X. Yuan, J.-H. Kim, C. Xu, J. Han, A. Agarwal, and A.-N. T. Kong
Mechanism of Action of Sulforaphane: Inhibition of p38 Mitogen-Activated Protein Kinase Isoforms Contributing to the Induction of Antioxidant Response Element-Mediated Heme Oxygenase-1 in Human Hepatoma HepG2 Cells
Cancer Res., September 1, 2006; 66(17): 8804 – 8813.
[Abstract] [Full Text] [PDF]

X. Yu, P. A. Egner, J. Wakabayashi, N. Wakabayashi, M. Yamamoto, and T. W. Kensler
Nrf2-mediated Induction of Cytoprotective Enzymes by 15-Deoxy-{Delta}12,14-Prostaglandin J2 Is Attenuated by Alkenal/one Oxidoreductase
J. Biol. Chem., September 8, 2006; 281(36): 26245 – 26252.
[Abstract] [Full Text] [PDF]

Calorie Restriction Extends Life Span— But Which Calories?
Leonie K. Heilbronn, Eric Ravussin
PLoS Medicine Vol. 2, No. 8, e231 DOI: 10.1371/journal.pmed.0020231
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  • Modelling the Impact of Antiretroviral Use in Resource-Poor Settings
    Rebecca F. Baggaley, Geoff P. Garnett, Neil M. Ferguson
    PLoS Medicine Vol. 3, No. 4, e124 DOI: 10.1371/journal.pmed.0030124
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  • Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index
    Shahrad Taheri, Ling Lin, Diane Austin, Terry Young, Emmanuel Mignot
    PLoS Medicine Vol. 1, No. 3, DOI: 10.1371/journal.pmed.0010062
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